The patient displays no evidence of local recurrence for 2 years postoperatively. Embolization of the tumor has been reported as an alternative approach; however, it remains insufficient due to the extensive vascular network of the tumor. The main localization of AA, which is limited to reproductive organ region, and the positive ER and PR status of the tumor suggest that AA may be a hormone-responsive neoplasm [ 1 ]. The mitotic activity was not observed. Adjuvant antihormonal therapy yields promising results for preventing recurrence. Thus, extensive surgery can be disregarded in patients with high morbidity and for preserving fertility, as well. All adjuvant treatment modalities remain controversial [ 8 ].

Mucoid and whirling after cutting. Case Reports in Surgery. Rev Med Hosp Gen Mex ; 70 2: A total colonoscopy found nothing else of note and ruled out other lesions as explanations of the single episode of self-limiting rectal bleeding. Further evidence is required to establish the true value of this treatment.

Aggressive angiomyxoma: a case series and literature review.

Since tumors are usually large, contiguous involvement of several sites is common 5. The tumor usually arises from the pelvic and perineal regions; however, uncommon localization has been reported in the literature [ 23 ].

View at Google Scholar J. This established the diagnosis of a presacral tumor Figure 1. Subsequently, abdominal ultrasonography USGcontrast-enhanced abdominal tomography CTand magnetic resonance imaging MRI were performed for estimating the tumor size, invasion degree of the mass, distant metastasis, and also ruling out other intra-abdominal lesions. MRI is more helpful than the other imaging studies. International Journal of Gynecological Cancer ; 8: View at Google Scholar I.

Aggressive angiomyxoma: A case series and literature review

The patient recovered uneventfully and was discharged from the hospital on postoperative day 8. Including broad free margins around the tumor in the area of resection should be the first step in preventing recurrences of this lesions, although this depends on tumor size, location and the presence or absence of disease within the surgical margin 1, 2, 6, 8.


Thus, we emphasize that although it is a rare condition, particularly, a female in reproductive age with a painless swelling located around the genitofemoral region should be well examined by imaging studies to rule out AA and to decide the surgical strategy, as well. The immunohistochemical findings of liteature present tumor confirmed positivity for both estrogen and progesterone receptors.

AA is a locally infiltrative slow growing tumor with a marked tendency to local recurrence.

aggressive angiomyxoma a case series and literature review

The mitotic activity was not observed. Kidric D, MacLennan G. Mitosis was not observed. Another important characteristic is that these lesions form masses that displace rather than infiltrate adjacent structures 3, 9. At the periphery of the lesion, the vessels were thicker due reivew perivascular hyalinization and medial hypertrophy. This is the best accepted hypothesis for their origins 1, 3, 6, The Journal of Urology ; It is likely due to the loose myxoid matrix and high-water content of AA [ 8 ].

Cosmetic results are satisfactory as a consequence of the approach selected, and there revies no alterations in anorectal continence.

Archive ouverte HAL – Aggressive angiomyxoma: A case series and literature review

Embolization of the tumor has been reported as an alternative approach; however, it remains insufficient due to the extensive vascular network of the tumor. In view of these data, the demographic characteristic and the tumor localization of our patient were similar to the majority of previously reported cases.

aggressive angiomyxoma a case series and literature review

Treatment of aggressive angiomyxoma with aromatase inhibitor prior to surgical resection. The tumor was extending to the left thigh via canal of Nuck. In addition they tend to have fusiform or stellate literrature with relatively scarce eosinophilic cytoplasm in a myxoid base. However, there are series of cases which have reported no differences in rates of recurrence among patients with negative surgical margins and those with positive margins.


The cells of this neoplasm typically express estrogen and progesterone receptors which suggests hormonal influence on the development and growth of the lesion and that the angiomyxoma may arise from specialized cells of the stroma of the perineum.

aggressive angiomyxoma a case series and literature review

Laparotomy was performed through a midline incision that extends to the left thigh. AA is regarded as an aggressive tumor due to the neoplastic nature of the blood vessels and its high tendency of local infiltration and local recurrence. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.

The evolution of the disease in one of these patients took 10 years from diagnosis while in the other it took 27 years. The rectum is fully w to the xngiomyxoma of the elevators muscles, and then the mass in adjacent planes is dissected.

In her medical history, the patient declared that she aggressive a large painless swelling extending from her left groin to her left leg which grew gradually during one year.

They are whitish with pink or red outer surfaces and gray colored cross sections resulting from myxoid stroma that is rich in collagen fibers. According to the histopathological and immunohistochemical findings, the case was interpreted as intra-abdominal aggressive angiomyxoma.